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Target
Hormone-sensitive lipase
Ligand
BDBM50142719
Substrate
n/a
Meas. Tech.
ChEBML_88047
IC50
1±n/a nM
Citation
 de Jong, JC; Sørensen, LG; Tornqvist, H; Jacobsen, P Carbazates as potent inhibitors of hormone-sensitive lipase. Bioorg Med Chem Lett 14:1741-4 (2004) [PubMed]  Article 
Target
Name:
Hormone-sensitive lipase
Synonyms:
HSL | Hormone sensitive lipase | Hormone-sensitive lipase (HSL) | LIPE | LIPS_HUMAN
Type:
Protein
Mol. Mass.:
116599.07
Organism:
Homo sapiens (Human)
Description:
Q05469
Residue:
1076
Sequence:
MEPGSKSVSRSDWQPEPHQRPITPLEPGPEKTPIAQPESKTLQGSNTQQKPASNQRPLTQQETPAQHDAESQKEPRAQQKSASQEEFLAPQKPAPQQSPYIQRVLLTQQEAASQQGPGLGKESITQQEPALRQRHVAQPGPGPGEPPPAQQEAESTPAAQAKPGAKREPSAPTESTSQETPEQSDKQTTPVQGAKSKQGSLTELGFLTKLQELSIQRSALEWKALSEWVTDSESESDVGSSSDTDSPATMGGMVAQGVKLGFKGKSGYKVMSGYSGTSPHEKTSARNHRHYQDTASRLIHNMDLRTMTQSLVTLAEDNIAFFSSQGPGETAQRLSGVFAGVREQALGLEPALGRLLGVAHLFDLDPETPANGYRSLVHTARCCLAHLLHKSRYVASNRRSIFFRTSHNLAELEAYLAALTQLRALVYYAQRLLVTNRPGVLFFEGDEGLTADFLREYVTLHKGCFYGRCLGFQFTPAIRPFLQTISIGLVSFGEHYKRNETGLSVAASSLFTSGRFAIDPELRGAEFERITQNLDVHFWKAFWNITEMEVLSSLANMASATVRVSRLLSLPPEAFEMPLTADPTLTVTISPPLAHTGPGPVLVRLISYDLREGQDSEELSSLIKSNGQRSLELWPRPQQAPRSRSLIVHFHGGGFVAQTSRSHEPYLKSWAQELGAPIISIDYSLAPEAPFPRALEECFFAYCWAIKHCALLGSTGERICLAGDSAGGNLCFTVALRAAAYGVRVPDGIMAAYPATMLQPAASPSRLLSLMDPLLPLSVLSKCVSAYAGAKTEDHSNSDQKALGMMGLVRRDTALLLRDFRLGASSWLNSFLELSGRKSQKMSEPIAEPMRRSVSEAALAQPQGPLGTDSLKNLTLRDLSLRGNSETSSDTPEMSLSAETLSPSTPSDVNFLLPPEDAGEEAEAKNELSPMDRGLGVRAAFPEGFHPRRSSQGATQMPLYSSPIVKNPFMSPLLAPDSMLKSLPPVHIVACALDPMLDDSVMLARRLRNLGQPVTLRVVEDLPHGFLTLAALCRETRQAAELCVERIRLVLTPPAGAGPSGETGAAGVDGGCGGRH
  
Inhibitor
Name:
BDBM50142719
Synonyms:
CHEMBL49895 | Morpholin-4-yl-carbamic acid 4-[(4-tert-butyl-cyclohexanecarbonyl)-amino]-phenyl ester
Type:
Small organic molecule
Emp. Form.:
C22H33N3O4
Mol. Mass.:
403.5151
SMILES:
CC(C)(C)C1CCC(CC1)C(=O)Nc1ccc(OC(=O)NN2CCOCC2)cc1 |(18.92,2.31,;17.57,3.06,;17.56,4.61,;18.9,3.85,;16.23,2.28,;14.9,3.06,;13.57,2.28,;13.57,.76,;14.9,-.01,;16.23,.75,;12.24,-.01,;12.25,-1.55,;10.9,.76,;9.55,-.03,;8.21,.74,;6.87,-.03,;6.87,-1.57,;5.53,-2.35,;4.19,-1.57,;4.19,-.03,;2.86,-2.35,;1.5,-1.55,;.17,-2.32,;-1.16,-1.55,;-1.16,-.01,;.17,.76,;1.5,-.01,;8.21,-2.35,;9.55,-1.57,)|
Structure:
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