Reaction Details Report a problem with these data
Target
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
Ligand
BDBM50576308
Substrate
n/a
Meas. Tech.
ChEMBL_2126975 (CHEMBL4836320)
IC50
1449±n/a nM
Citation
 Wang, T; Zhang, R; Liu, Y; Fang, Z; Zhang, H; Fan, Y; Yang, S; Xiang, R Discovery of a new class of JMJD6 inhibitors and structure-activity relationship study. Bioorg Med Chem Lett 44:0 (2021) [PubMed]  Article 
Target
Name:
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
Synonyms:
1.14.11.- | Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 | Histone arginine demethylase JMJD6 | JMJD6 | JMJD6_HUMAN | JmjC domain-containing protein 6 | Jumonji domain-containing protein 6 | KIAA0585 | Lysyl-hydroxylase JMJD6 | PSR | PTDSR | Peptide-lysine 5-dioxygenase JMJD6 | Phosphatidylserine receptor | Protein PTDSR | Synonyms=KIAA0585
Type:
PROTEIN
Mol. Mass.:
46472.03
Organism:
Homo sapiens
Description:
ChEMBL_119095
Residue:
403
Sequence:
MNHKSKKRIREAKRSARPELKDSLDWTRHNYYESFSLSPAAVADNVERADALQLSVEEFVERYERPYKPVVLLNAQEGWSAQEKWTLERLKRKYRNQKFKCGEDNDGYSVKMKMKYYIEYMESTRDDSPLYIFDSSYGEHPKRRKLLEDYKVPKFFTDDLFQYAGEKRRPPYRWFVMGPPRSGTGIHIDPLGTSAWNALVQGHKRWCLFPTSTPRELIKVTRDEGGNQQDEAITWFNVIYPRTQLPTWPPEFKPLEILQKPGETVFVPGGWWHVVLNLDTTIAITQNFASSTNFPVVWHKTVRGRPKLSRKWYRILKQEHPELAVLADSVDLQESTGIASDSSSDSSSSSSSSSSDSDSECESGSEGDGTVHRRKKRRTCSMVGNGDTTSQDDCVSKERSSSR
  
Inhibitor
Name:
BDBM50576308
Synonyms:
CHEMBL4858652
Type:
Small organic molecule
Emp. Form.:
C12H12FN3O2
Mol. Mass.:
249.241
SMILES:
Cn1ccc(n1)-c1cc(ccn1)C(=O)OCCF
Structure:
Search PDB for entries with ligand similarity: