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Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM50142818
Substrate
n/a
Meas. Tech.
ChEBML_139762
Ki
9±n/a nM
Citation
 Palani, A; Dugar, S; Clader, JW; Greenlee, WJ; Ruperto, V; Duffy, RA; Lachowicz, JE Isopropyl amide derivatives of potent and selective muscarinic M2 receptor antagonists. Bioorg Med Chem Lett 14:1791-4 (2004) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2
Type:
GPCR
Mol. Mass.:
51730.61
Organism:
Homo sapiens (Human)
Description:
P08172
Residue:
466
Sequence:
MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
  
Inhibitor
Name:
BDBM50142818
Synonyms:
CHEMBL300845 | N-Isopropyl-4-{2-[1'-(2-methyl-benzoyl)-[1,4']bipiperidinyl-4-yl]-[1,3]dioxolan-2-yl}-benzamide
Type:
Small organic molecule
Emp. Form.:
C31H41N3O4
Mol. Mass.:
519.6749
SMILES:
CC(C)NC(=O)c1ccc(cc1)C1(OCCO1)C1CCN(CC1)C1CCN(CC1)C(=O)c1ccccc1C
Structure:
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