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Target
GTPase KRas
Ligand
BDBM50576725
Substrate
n/a
Meas. Tech.
ChEMBL_2127756 (CHEMBL4837101)
IC50
1.5±n/a nM
Citation
 Kargbo, RB Targeting the KRAS G12D Mutant as Potential Therapy in Cancer. ACS Med Chem Lett 12:1212-1213 (2021) [PubMed]  Article 
Target
Name:
GTPase KRas
Synonyms:
GTPase KRas, N-terminally processed | K-Ras 2 | KRAS | KRAS2 | Ki-Ras | RASK2 | RASK_HUMAN | c-K-ras | c-Ki-ras
Type:
PROTEIN
Mol. Mass.:
21656.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1476955
Residue:
189
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM
  
Inhibitor
Name:
BDBM50576725
Synonyms:
CHEMBL4875572 | US20230348495, Example 2
Type:
Small organic molecule
Emp. Form.:
C32H38BrFN6O2
Mol. Mass.:
637.586
SMILES:
Oc1cc(N2CCc3c(C2)nc(OCC2(CN4CC[C@@H](F)C4)CC2)nc3N2CC3CCC(C2)N3)c2c(Br)cccc2c1 |r|
Structure:
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