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Target
C-C chemokine receptor type 1
Ligand
BDBM50144393
Substrate
n/a
Meas. Tech.
ChEBML_41887
IC50
26±n/a nM
Citation
 Kath, JC; Brissette, WH; Brown, MF; Conklyn, M; DiRico, AP; Dorff, P; Gladue, RP; Lillie, BM; Lira, PD; Mairs, EN; Martin, WH; McElroy, EB; McGlynn, MA; Paradis, TJ; Poss, CS; Stock, IA; Tylaska, LA; Zheng, D Potent small molecule CCR1 antagonists. Bioorg Med Chem Lett 14:2169-73 (2004) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 1
Synonyms:
C-C CKR-1 | C-C chemokine receptor type 1 (CCR1) | CC-CKR-1 | CCR-1 | CCR1 | CCR1_HUMAN | CD_antigen=CD191 | CMKBR1 | CMKR1 | HM145 | LD78 receptor | MIP-1alpha-R | Macrophage inflammatory protein 1-alpha receptor | RANTES-R | SCYAR1
Type:
Enzyme
Mol. Mass.:
41180.69
Organism:
Homo sapiens (Human)
Description:
P32246
Residue:
355
Sequence:
METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLVQYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTHHTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRLIFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVIYAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF
  
Inhibitor
Name:
BDBM50144393
Synonyms:
CHEMBL69274 | Quinoxaline-2-carboxylic acid ((1S,2S,4S)-1-benzyl-4-carbamoyl-4-cyclopentyl-2-hydroxy-butyl)-amide
Type:
Small organic molecule
Emp. Form.:
C26H30N4O3
Mol. Mass.:
446.5414
SMILES:
NC(=O)[C@@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCCC1
Structure:
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