Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 1
Ligand
BDBM50144421
Substrate
n/a
Meas. Tech.
ChEMBL_41888 (CHEMBL655681)
IC50
20±n/a nM
Citation
Brown, MF; Avery, M; Brissette, WH; Chang, JH; Colizza, K; Conklyn, M; DiRico, AP; Gladue, RP; Kath, JC; Krueger, SS; Lira, PD; Lillie, BM; Lundquist, GD; Mairs, EN; McElroy, EB; McGlynn, MA; Paradis, TJ; Poss, CS; Rossulek, MI; Shepard, RM; Sims, J; Strelevitz, TJ; Truesdell, S; Tylaska, LA; Yoon, K; Zheng, D Novel CCR1 antagonists with improved metabolic stability. Bioorg Med Chem Lett 14:2175-9 (2004) [PubMed] Article
More Info.:
Target
Name:
C-C chemokine receptor type 1
Synonyms:
C-C CKR-1 | C-C chemokine receptor type 1 (CCR1) | CC-CKR-1 | CCR-1 | CCR1 | CCR1_HUMAN | CD_antigen=CD191 | CMKBR1 | CMKR1 | HM145 | LD78 receptor | MIP-1alpha-R | Macrophage inflammatory protein 1-alpha receptor | RANTES-R | SCYAR1
Type:
Enzyme
Mol. Mass.:
41180.69
Organism:
Homo sapiens (Human)
Description:
P32246
Residue:
355
Sequence:
METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLVQYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTHHTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRLIFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVIYAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF
Inhibitor
Name:
BDBM50144421
Synonyms:
CHEMBL302533 | Quinoxaline-2-carboxylic acid [(1S,2S)-1-benzyl-4-carbamoyl-4-(4,4-difluoro-cyclohexyl)-2-hydroxy-butyl]-amide
Type:
Small organic molecule
Emp. Form.:
C27H30F2N4O3
Mol. Mass.:
496.5489
SMILES:
NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCC(F)(F)CC1