Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase Lyn
Ligand
BDBM50506460
Substrate
n/a
Meas. Tech.
ChEMBL_2130170 (CHEMBL4839599)
IC50
7.0±n/a nM
Citation
 Xie, Z; Xiang, C; Li, X; Fan, C; Chen, T; Liu, M; Ma, Y; Bai, F; Tang, W; Hu, Y Discovery of Potent Antiallergic Agents Based on an  J Med Chem 64:13588-13603 (2021) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase Lyn
Synonyms:
JTK8 | LYN | LYN_HUMAN | Lck/Yes-related novel protein tyrosine kinase | Tyrosine-protein kinase Lyn (LYN) | V-yes-1 Yamaguchi sarcoma viral related oncogene homolog | p53Lyn | p56Lyn
Type:
Protein
Mol. Mass.:
58575.92
Organism:
Homo sapiens (Human)
Description:
P07948
Residue:
512
Sequence:
MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
  
Inhibitor
Name:
BDBM50506460
Synonyms:
CHEMBL4467948
Type:
Small organic molecule
Emp. Form.:
C25H19Cl2N5O
Mol. Mass.:
476.357
SMILES:
Cc1ccc(cc1C#Cc1cc(cnc1N)-c1cnn(C)c1)C(=O)Nc1ccc(Cl)cc1Cl
Structure:
Search PDB for entries with ligand similarity: