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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50144640
Substrate
n/a
Meas. Tech.
ChEBML_71592
Ki
0.700000±n/a nM
Citation
 Rowbottom, MW; Tucci, FC; Zhu, YF; Guo, Z; Gross, TD; Reinhart, GJ; Xie, Q; Struthers, RS; Saunders, J; Chen, C Synthesis and structure-activity relationships of (R)-1-alkyl-3-[2-(2-amino)phenethyl]-5-(2-fluorophenyl)-6-methyluracils as human GnRH receptor antagonists. Bioorg Med Chem Lett 14:2269-74 (2004) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH)
Type:
Enzyme
Mol. Mass.:
37749.45
Organism:
Homo sapiens (Human)
Description:
P30968
Residue:
328
Sequence:
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50144640
Synonyms:
3-((R)-2-Amino-2-phenyl-ethyl)-1-(2-chloro-6-fluoro-benzyl)-5-(2-fluoro-phenyl)-6-methyl-1H-pyrimidine-2,4-dione; TFA | CHEMBL75347
Type:
Small organic molecule
Emp. Form.:
C26H22ClF2N3O2
Mol. Mass.:
481.922
SMILES:
Cc1c(-c2ccccc2F)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1Cl |wD:14.15,(5.34,.51,;3.8,.51,;3.03,1.84,;3.8,3.17,;5.34,3.17,;6.11,4.5,;5.34,5.85,;3.79,5.83,;3.03,4.5,;1.49,4.5,;1.49,1.84,;.71,3.17,;.73,.51,;-.81,.51,;-2.14,-.26,;-2.14,-1.8,;-3.47,.51,;-3.47,2.05,;-4.81,2.82,;-6.14,2.05,;-6.14,.51,;-4.81,-.26,;1.5,-.82,;.73,-2.15,;3.03,-.82,;3.8,-2.15,;3.03,-3.49,;1.49,-3.49,;1.89,-1.99,;.72,-4.82,;1.49,-6.15,;3.04,-6.15,;3.8,-4.81,;5.34,-4.79,)|
Structure:
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