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Target
Dual specificity mitogen-activated protein kinase kinase 4
Ligand
BDBM50577686
Substrate
n/a
Meas. Tech.
ChEMBL_2130725 (CHEMBL4840154)
IC50
290±n/a nM
Citation
 Kwong, AJ; Pham, TND; Oelschlager, HE; Munshi, HG; Scheidt, KA Rational Design, Optimization, and Biological Evaluation of Novel MEK4 Inhibitors against Pancreatic Adenocarcinoma. ACS Med Chem Lett 12:1559-1567 (2021) [PubMed]  Article 
Target
Name:
Dual specificity mitogen-activated protein kinase kinase 4
Synonyms:
JNK-activating kinase 1 | JNKK | JNKK1 | MAP kinase kinase 4 | MAP2K4 | MEK4 | MKK4 | MP2K4_HUMAN | PRKMK4 | SAPK/ERK kinase 1 | SEK1 | SERK1 | SKK1 | c-Jun N-terminal kinase kinase 1
Type:
PROTEIN
Mol. Mass.:
44294.29
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1460558
Residue:
399
Sequence:
MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQGKRKALKLNFANPPFKSTARFTLNPNPTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVCKILDQMPATPSSPMYVD
  
Inhibitor
Name:
BDBM50577686
Synonyms:
CHEMBL4865159
Type:
Small organic molecule
Emp. Form.:
C20H16FN3O4S2
Mol. Mass.:
445.487
SMILES:
CS(=O)(=O)c1ccc(NS(=O)(=O)c2cccc(c2)-c2n[nH]c3cc(F)ccc23)cc1
Structure:
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