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Target
Cyclin-dependent kinase 5
Ligand
BDBM50139171
Substrate
n/a
Meas. Tech.
ChEMBL_2131736 (CHEMBL4841251)
IC50
1.000000±n/a nM
Citation
 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia. J Med Chem 64:14647-14663 (2021) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 5
Synonyms:
CDK5 | CDK5_HUMAN | CDKN5 | Cell division protein kinase 5 | Cyclin-dependent kinase 5 (CDK5/ p25) | Cyclin-dependent kinase 5 (CDK5/p35) | Cyclin-dependent-like kinase 5 | Cyclin-dependent-like kinase 5 (CDK5) | PSSALRE | Serine/threonine-protein kinase PSSALRE | Tau protein kinase II catalytic subunit
Type:
Enzyme Subunit
Mol. Mass.:
33308.61
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
292
Sequence:
MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP
  
Inhibitor
Name:
BDBM50139171
Synonyms:
Dinaciclib | MK-7965 | SCH-727965 | US11643396, Example Dinaciclib | US20230416221, Compound Dinaciclib
Type:
Small organic molecule
Emp. Form.:
C21H28N6O2
Mol. Mass.:
396.486
SMILES:
CCc1cnn2c(NCc3ccc[n+]([O-])c3)cc(nc12)N1CCCC[C@H]1CCO |r|
Structure:
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