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Target
Vitamin D3 receptor
Ligand
BDBM50145539
Substrate
n/a
Meas. Tech.
ChEBML_214183
IC50
0.500000±n/a nM
Citation
 Kato, Y; Nakano, Y; Sano, H; Tanatani, A; Kobayashi, H; Shimazawa, R; Koshino, H; Hashimoto, Y; Nagasawa, K Synthesis of 1alpha,25-dihydroxyvitamin D3-26,23-lactams (DLAMs), a novel series of 1 alpha,25-dihydroxyvitamin D3 antagonist. Bioorg Med Chem Lett 14:2579-83 (2004) [PubMed]  Article 
Target
Name:
Vitamin D3 receptor
Synonyms:
NR1I1 | VDR | VDR_CHICK | Vitamin D receptor
Type:
PROTEIN
Mol. Mass.:
51292.53
Organism:
Gallus gallus
Description:
ChEMBL_214183
Residue:
451
Sequence:
MSELRGSWDEQQQSMAYLPDADMDTVAASTSLPDPAGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKAMFTCPFNGDCKITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKESLKPKLSEEQQKVIDTLLEAHHKTFDTTYSDFNKFRPPVRSKFSSRMATHSSSVVSQDFSSEDSNDVFGSDAFAAFPEPMEPQMFSNLDLSEESDESPSMNIELPHLPMLPHLADLVSYSIQKVIGFAKMIPGFRDLTAEDQIALLKSSAIEVIMLRSNQSFTMEDMSWTCGSNDFKYKVSDVTQAGHSMDLLEPLVKFQVGLKKLNLHEEEHVLLMAICILSPDRPGVQDTSLVESIQDRLSDILQTYIRCRHPPPGSRLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPEHSMQLTPLVLEVFGNEIS
  
Inhibitor
Name:
BDBM50145539
Synonyms:
(2S,4R)-2,4-Dihydroxy-6-[2-[(R)-1-((R)-5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4Z)-ylidene]-eth-(E)-ylidene]-cyclohexanone | CHEMBL431606
Type:
Small organic molecule
Emp. Form.:
C26H42O4
Mol. Mass.:
418.6093
SMILES:
C[C@H](CCCC(C)(C)O)C1CCC2C(CCC[C@]12C)=CCC1C[C@@H](O)CC(=O)C1=O |w:19.21|
Structure:
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