Reaction Details Report a problem with these data
Target
Cannabinoid receptor 1
Ligand
BDBM50398222
Substrate
n/a
Meas. Tech.
ChEMBL_2132884 (CHEMBL4842494)
Ki
2630±n/a nM
Citation
 Mohr, F; Hurrle, T; Burggraaff, L; Langer, L; Bemelmans, MP; Knab, M; Nieger, M; van Westen, GJP; Heitman, LH; Bräse, S Synthesis and SAR evaluation of coumarin derivatives as potent cannabinoid receptor agonists. Eur J Med Chem 220:0 (2021) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52868.96
Organism:
Homo sapiens (Human)
Description:
P21554
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50398222
Synonyms:
CHEMBL2177264
Type:
Small organic molecule
Emp. Form.:
C25H30O3
Mol. Mass.:
378.5039
SMILES:
CCCCCCC(C)(C)c1cc(O)c2cc(Cc3ccccc3)c(=O)oc2c1
Structure:
Search PDB for entries with ligand similarity: