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Target
Histamine H3 receptor
Ligand
BDBM50146141
Substrate
n/a
Meas. Tech.
ChEMBL_83636 (CHEMBL695766)
EC50
311±n/a nM
Citation
 Meier, G; Krause, M; Hüls, A; Ligneau, X; Pertz, HH; Arrang, JM; Ganellin, CR; Schwartz, JC; Schunack, W; Stark, H 4-(omega-(alkyloxy)alkyl)-1H-imidazole derivatives as histamine H(3) receptor antagonists/agonists. J Med Chem 47:2678-87 (2004) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50146141
Synonyms:
4-(3-Butoxy-propyl)-1H-imidazole; compound with (Z)-but-2-enedioic acid | CHEMBL314526
Type:
Small organic molecule
Emp. Form.:
C10H18N2O
Mol. Mass.:
182.2627
SMILES:
CCCCOCCCc1cnc[nH]1
Structure:
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