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Target
GTPase KRas
Ligand
BDBM50579601
Substrate
n/a
Meas. Tech.
ChEMBL_2135940 (CHEMBL4845550)
IC50
0.400000±n/a nM
Citation
 Kargbo, RB Targeting KRAS G12D Mutant for the Potential Treatment of Pancreatic Cancer. ACS Med Chem Lett 12:1643-1645 (2021) [PubMed]  Article 
Target
Name:
GTPase KRas
Synonyms:
GTPase KRas, N-terminally processed | K-Ras 2 | KRAS | KRAS2 | Ki-Ras | RASK2 | RASK_HUMAN | c-K-ras | c-Ki-ras
Type:
PROTEIN
Mol. Mass.:
21656.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1476955
Residue:
189
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM
  
Inhibitor
Name:
BDBM50579601
Synonyms:
CHEMBL4858364 | US11453683, Example 252 | US20230279025, Example 481
Type:
Small organic molecule
Emp. Form.:
C33H31F3N6O2
Mol. Mass.:
600.6334
SMILES:
Oc1cc(-c2ncc3c(nc(OC[C@@]45CCCN4C[C@H](F)C5)nc3c2F)N2CC3CCC(C2)N3)c2c(C#C)c(F)ccc2c1 |r|
Structure:
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