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Target
GTPase KRas
Ligand
BDBM50579602
Substrate
n/a
Meas. Tech.
ChEMBL_2135940 (CHEMBL4845550)
IC50
0.800000±n/a nM
Citation
 Kargbo, RB Targeting KRAS G12D Mutant for the Potential Treatment of Pancreatic Cancer. ACS Med Chem Lett 12:1643-1645 (2021) [PubMed]  Article 
Target
Name:
GTPase KRas
Synonyms:
GTPase KRas, N-terminally processed | K-Ras 2 | KRAS | KRAS2 | Ki-Ras | RASK2 | RASK_HUMAN | c-K-ras | c-Ki-ras
Type:
PROTEIN
Mol. Mass.:
21656.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1476955
Residue:
189
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM
  
Inhibitor
Name:
BDBM50579602
Synonyms:
CHEMBL4863371 | US11453683, Example 253 | US20230279025, Example 253
Type:
Small organic molecule
Emp. Form.:
C33H35F3N6O2
Mol. Mass.:
604.6652
SMILES:
CCc1c(F)ccc2cc(O)cc(-c3ncc4c(nc(OC[C@@]56CCCN5C[C@H](F)C6)nc4c3F)N3CC4CCC(C3)N4)c12 |r|
Structure:
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