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Target
GTPase KRas
Ligand
BDBM50579604
Substrate
n/a
Meas. Tech.
ChEMBL_2135940 (CHEMBL4845550)
IC50
0.600000±n/a nM
Citation
 Kargbo, RB Targeting KRAS G12D Mutant for the Potential Treatment of Pancreatic Cancer. ACS Med Chem Lett 12:1643-1645 (2021) [PubMed]  Article 
Target
Name:
GTPase KRas
Synonyms:
GTPase KRas, N-terminally processed | K-Ras 2 | KRAS | KRAS2 | Ki-Ras | RASK2 | RASK_HUMAN | c-K-ras | c-Ki-ras
Type:
PROTEIN
Mol. Mass.:
21656.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1476955
Residue:
189
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM
  
Inhibitor
Name:
BDBM50579604
Synonyms:
CHEMBL4876243 | US11453683, Example 388 | US20230279025, Example 388
Type:
Small organic molecule
Emp. Form.:
C32H34F2N6O3
Mol. Mass.:
588.6476
SMILES:
COC1CN2CCCC2(COc2nc(N3CC4CCC(C3)N4)c3cnc(c(F)c3n2)-c2cc(O)cc3cccc(F)c23)C1
Structure:
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