Reaction Details Report a problem with these data
Target
Hormone-sensitive lipase
Ligand
BDBM50147297
Substrate
n/a
Meas. Tech.
ChEBML_88045
IC50
1±n/a nM
Citation
 Lowe, DB; Magnuson, S; Qi, N; Campbell, AM; Cook, J; Hong, Z; Wang, M; Rodriguez, M; Achebe, F; Kluender, H; Wong, WC; Bullock, WH; Salhanick, AI; Witman-Jones, T; Bowling, ME; Keiper, C; Clairmont, KB In vitro SAR of (5-(2H)-isoxazolonyl) ureas, potent inhibitors of hormone-sensitive lipase. Bioorg Med Chem Lett 14:3155-9 (2004) [PubMed]  Article 
Target
Name:
Hormone-sensitive lipase
Synonyms:
HSL | Hormone sensitive lipase | Hormone-sensitive lipase (HSL) | LIPE | LIPS_HUMAN
Type:
Protein
Mol. Mass.:
116599.07
Organism:
Homo sapiens (Human)
Description:
Q05469
Residue:
1076
Sequence:
MEPGSKSVSRSDWQPEPHQRPITPLEPGPEKTPIAQPESKTLQGSNTQQKPASNQRPLTQQETPAQHDAESQKEPRAQQKSASQEEFLAPQKPAPQQSPYIQRVLLTQQEAASQQGPGLGKESITQQEPALRQRHVAQPGPGPGEPPPAQQEAESTPAAQAKPGAKREPSAPTESTSQETPEQSDKQTTPVQGAKSKQGSLTELGFLTKLQELSIQRSALEWKALSEWVTDSESESDVGSSSDTDSPATMGGMVAQGVKLGFKGKSGYKVMSGYSGTSPHEKTSARNHRHYQDTASRLIHNMDLRTMTQSLVTLAEDNIAFFSSQGPGETAQRLSGVFAGVREQALGLEPALGRLLGVAHLFDLDPETPANGYRSLVHTARCCLAHLLHKSRYVASNRRSIFFRTSHNLAELEAYLAALTQLRALVYYAQRLLVTNRPGVLFFEGDEGLTADFLREYVTLHKGCFYGRCLGFQFTPAIRPFLQTISIGLVSFGEHYKRNETGLSVAASSLFTSGRFAIDPELRGAEFERITQNLDVHFWKAFWNITEMEVLSSLANMASATVRVSRLLSLPPEAFEMPLTADPTLTVTISPPLAHTGPGPVLVRLISYDLREGQDSEELSSLIKSNGQRSLELWPRPQQAPRSRSLIVHFHGGGFVAQTSRSHEPYLKSWAQELGAPIISIDYSLAPEAPFPRALEECFFAYCWAIKHCALLGSTGERICLAGDSAGGNLCFTVALRAAAYGVRVPDGIMAAYPATMLQPAASPSRLLSLMDPLLPLSVLSKCVSAYAGAKTEDHSNSDQKALGMMGLVRRDTALLLRDFRLGASSWLNSFLELSGRKSQKMSEPIAEPMRRSVSEAALAQPQGPLGTDSLKNLTLRDLSLRGNSETSSDTPEMSLSAETLSPSTPSDVNFLLPPEDAGEEAEAKNELSPMDRGLGVRAAFPEGFHPRRSSQGATQMPLYSSPIVKNPFMSPLLAPDSMLKSLPPVHIVACALDPMLDDSVMLARRLRNLGQPVTLRVVEDLPHGFLTLAALCRETRQAAELCVERIRLVLTPPAGAGPSGETGAAGVDGGCGGRH
  
Inhibitor
Name:
BDBM50147297
Synonyms:
4-Isopropyl-2-[4-(3-methoxy-phenyl)-piperazine-1-carbonyl]-3-methyl-2H-isoxazol-5-one | CHEMBL419197
Type:
Small organic molecule
Emp. Form.:
C19H25N3O4
Mol. Mass.:
359.4195
SMILES:
COc1cccc(c1)N1CCN(CC1)C(=O)n1oc(=O)c(C(C)C)c1C
Structure:
Search PDB for entries with ligand similarity: