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Target
Cruzipain
Ligand
BDBM50148056
Substrate
n/a
Meas. Tech.
ChEMBL_51851 (CHEMBL664074)
IC50
>20000±n/a nM
Citation
 Greenbaum, DC; Mackey, Z; Hansell, E; Doyle, P; Gut, J; Caffrey, CR; Lehrman, J; Rosenthal, PJ; McKerrow, JH; Chibale, K Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi. J Med Chem 47:3212-9 (2004) [PubMed]  Article 
Target
Name:
Cruzipain
Synonyms:
CYSP_TRYCR | Cruzain | Cruzaine | Major cysteine proteinase
Type:
Protein
Mol. Mass.:
49831.41
Organism:
Trypanosoma cruzi
Description:
P25779
Residue:
467
Sequence:
MSGWARALLLAAVLVVMACLVPAATASLHAEETLTSQFAEFKQKHGRVYESAAEEAFRLSVFRENLFLARLHAAANPHATFGVTPFSDLTREEFRSRYHNGAAHFAAAQERARVPVKVEVVGAPAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFLAGHPLTNLSEQMLVSCDKTDSGCSGGLMNNAFEWIVQENNGAVYTEDSYPYASGEGISPPCTTSGHTVGATITGHVELPQDEAQIAAWLAVNGPVAVAVDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDSAAVPYWIIKNSWTTQWGEEGYIRIAKGSNQCLVKEEASSAVVGGPGPTPEPTTTTTTSAPGPSPSYFVQMSCTDAACIVGCENVTLPTGQCLLTTSGVSAIVTCGAETLTEEVFLTSTHCSGPSVRSSVPLNKCNRLLRGSVEFFCGSSSSGRLADVDRQRRHQPYHSRHRRL
  
Inhibitor
Name:
BDBM50148056
Synonyms:
(1E)-1-pyridin-2-ylethan-1-one thiosemicarbazone | 2-(1-(pyridin-2-yl)ethylidene)hydrazinecarbothioamide | 2-acetylpyridine thiosemicarbazone | 2-acetylpyridinethiosemicarbazone | 4-(1-pyridin-2-yl ethylene) thiosemicarbazone | CHEMBL416771
Type:
Small organic molecule
Emp. Form.:
C8H10N4S
Mol. Mass.:
194.257
SMILES:
CC(=NNC(N)=S)c1ccccn1 |w:2.2|
Structure:
Search PDB for entries with ligand similarity: