Reaction Details Report a problem with these data
Target
Bis(5'-adenosyl)-triphosphatase
Ligand
BDBM50580671
Substrate
n/a
Meas. Tech.
ChEMBL_2148869 (CHEMBL5033267)
IC50
8800±n/a nM
Citation
 Kawaguchi, M; Sekimoto, E; Ohta, Y; Ieda, N; Murakami, T; Nakagawa, H Synthesis of Fluorescent Probes Targeting Tumor-Suppressor Protein FHIT and Identification of Apoptosis-Inducing FHIT Inhibitors. J Med Chem 64:9567-9576 (2021) [PubMed]  Article 
Target
Name:
Bis(5'-adenosyl)-triphosphatase
Synonyms:
AP3A hydrolase | AP3Aase | Bis(5'adenosyl)-triphosphatase | Dinucleosidetriphosphatase | FHIT | FHIT_HUMAN | Fragile histidine triad protein
Type:
Protein
Mol. Mass.:
16861.00
Organism:
Homo sapiens (Human)
Description:
P49789
Residue:
147
Sequence:
MSFRFGQHLIKPSVVFLKTELSFALVNRKPVVPGHVLVCPLRPVERFHDLRPDEVADLFQTTQRVGTVVEKHFHGTSLTFSMQDGPEAGQTVKHVHVHVLPRKAGDFHRNDSIYEELQKHDKEDFPASWRSEEEMAAEAAALRVYFQ
  
Inhibitor
Name:
BDBM50580671
Synonyms:
CHEMBL5083166
Type:
Small organic molecule
Emp. Form.:
C24H20BrNO2
Mol. Mass.:
434.325
SMILES:
CC1(C)CC(=O)C2=C(C1)NC1=C(C2c2ccc(Br)cc2)C(=O)c2ccccc12 |c:6,11|
Structure:
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