Reaction Details Report a problem with these data
Target
Bis(5'-adenosyl)-triphosphatase
Ligand
BDBM50580673
Substrate
n/a
Meas. Tech.
ChEMBL_2148869 (CHEMBL5033267)
IC50
4660±n/a nM
Citation
 Kawaguchi, M; Sekimoto, E; Ohta, Y; Ieda, N; Murakami, T; Nakagawa, H Synthesis of Fluorescent Probes Targeting Tumor-Suppressor Protein FHIT and Identification of Apoptosis-Inducing FHIT Inhibitors. J Med Chem 64:9567-9576 (2021) [PubMed]  Article 
Target
Name:
Bis(5'-adenosyl)-triphosphatase
Synonyms:
AP3A hydrolase | AP3Aase | Bis(5'adenosyl)-triphosphatase | Dinucleosidetriphosphatase | FHIT | FHIT_HUMAN | Fragile histidine triad protein
Type:
Protein
Mol. Mass.:
16861.00
Organism:
Homo sapiens (Human)
Description:
P49789
Residue:
147
Sequence:
MSFRFGQHLIKPSVVFLKTELSFALVNRKPVVPGHVLVCPLRPVERFHDLRPDEVADLFQTTQRVGTVVEKHFHGTSLTFSMQDGPEAGQTVKHVHVHVLPRKAGDFHRNDSIYEELQKHDKEDFPASWRSEEEMAAEAAALRVYFQ
  
Inhibitor
Name:
BDBM50580673
Synonyms:
CHEMBL1520857
Type:
Small organic molecule
Emp. Form.:
C17H18N4O3
Mol. Mass.:
326.3498
SMILES:
CC1CCc2c(C1)c1ccc(OCc3nn[nH]n3)c(C)c1oc2=O
Structure:
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