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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50149267
Substrate
n/a
Meas. Tech.
ChEMBL_71435 (CHEMBL685307)
Ki
973.0±n/a nM
Citation
 Tucci, FC; Zhu, YF; Guo, Z; Gross, TD; Connors, PJ; Gao, Y; Rowbottom, MW; Struthers, RS; Reinhart, GJ; Xie, Q; Chen, TK; Bozigian, H; Killam Bonneville, AL; Fisher, A; Jin, L; Saunders, J; Chen, C 3-(2-aminoalkyl)-1-(2,6-difluorobenzyl)-5- (2-fluoro-3-methoxyphenyl)-6-methyl-uracils as orally bioavailable antagonists of the human gonadotropin releasing hormone receptor. J Med Chem 47:3483-6 (2004) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH)
Type:
Enzyme
Mol. Mass.:
37749.45
Organism:
Homo sapiens (Human)
Description:
P30968
Residue:
328
Sequence:
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50149267
Synonyms:
3-((S)-2-Amino-3-methyl-butyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione | CHEMBL119739
Type:
Small organic molecule
Emp. Form.:
C24H26F3N3O3
Mol. Mass.:
461.4767
SMILES:
COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@@H](N)C(C)C)c1=O |wD:26.28,(23.22,8.17,;21.87,7.4,;21.87,5.87,;23.22,5.09,;23.22,3.54,;21.87,2.78,;20.54,3.56,;20.54,5.09,;19.21,5.87,;19.21,2.79,;19.21,1.26,;20.54,.49,;17.87,.48,;17.87,-1.06,;19.2,-1.83,;19.2,-3.37,;17.86,-4.14,;20.53,-4.14,;21.87,-3.37,;21.87,-1.83,;20.53,-1.06,;21.61,.04,;16.54,1.25,;15.2,.49,;16.54,2.8,;15.21,3.57,;13.87,2.82,;12.54,3.59,;13.87,1.28,;12.54,.51,;14.26,-.22,;17.88,3.57,;17.88,5.11,)|
Structure:
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