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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50149270
Substrate
n/a
Meas. Tech.
ChEMBL_71435 (CHEMBL685307)
Ki
94±n/a nM
Citation
 Tucci, FC; Zhu, YF; Guo, Z; Gross, TD; Connors, PJ; Gao, Y; Rowbottom, MW; Struthers, RS; Reinhart, GJ; Xie, Q; Chen, TK; Bozigian, H; Killam Bonneville, AL; Fisher, A; Jin, L; Saunders, J; Chen, C 3-(2-aminoalkyl)-1-(2,6-difluorobenzyl)-5- (2-fluoro-3-methoxyphenyl)-6-methyl-uracils as orally bioavailable antagonists of the human gonadotropin releasing hormone receptor. J Med Chem 47:3483-6 (2004) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH)
Type:
Enzyme
Mol. Mass.:
37749.45
Organism:
Homo sapiens (Human)
Description:
P30968
Residue:
328
Sequence:
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50149270
Synonyms:
3-((S)-2-Amino-2-cyclopentyl-ethyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione | CHEMBL119185
Type:
Small organic molecule
Emp. Form.:
C26H28F3N3O3
Mol. Mass.:
487.514
SMILES:
COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@@H](N)C2CCCC2)c1=O |wD:26.28,(26.35,5.99,;25.01,5.22,;25.01,3.68,;26.35,2.91,;26.35,1.37,;25.01,.6,;23.68,1.38,;23.68,2.91,;22.35,3.69,;22.34,.62,;22.34,-.92,;23.67,-1.69,;21.01,-1.7,;21.01,-3.24,;22.34,-4.01,;22.34,-5.55,;21,-6.32,;23.67,-6.32,;25,-5.55,;25,-4,;23.67,-3.23,;24.76,-2.13,;19.68,-.92,;19.65,-2.39,;19.68,.62,;18.35,1.39,;17.01,.63,;15.68,1.4,;17.01,-.91,;18.25,-1.8,;17.76,-3.27,;16.22,-3.27,;15.76,-1.8,;21.01,1.39,;21.02,2.93,)|
Structure:
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