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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50149716
Substrate
n/a
Meas. Tech.
ChEMBL_302559 (CHEMBL839522)
Ki
65.9±n/a nM
Citation
 Chackalamannil, S; Doller, D; McQuade, R; Ruperto, V Himbacine analogs as muscarinic receptor antagonists--effects of tether and heterocyclic variations. Bioorg Med Chem Lett 14:3967-70 (2004) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50149716
Synonyms:
(3S,3aS,4aS,8aR,9aS)-4-[2-((2R,6S)-1,6-Dimethyl-piperidin-2-yl)-eth-(Z)-ylidene]-3-methyl-decahydro-naphtho[2,3-c]furan-1-one | CHEMBL182761
Type:
Small organic molecule
Emp. Form.:
C22H35NO2
Mol. Mass.:
345.5188
SMILES:
C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3\C(=C\C[C@H]3CCC[C@H](C)N3C)[C@@H]12
Structure:
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