Reaction Details Report a problem with these data
Target
Phenylethanolamine N-methyltransferase
Ligand
BDBM50081952
Substrate
n/a
Meas. Tech.
ChEMBL_303166 (CHEMBL829978)
Ki
4.9±n/a nM
Citation
 Wu, Q; Criscione, KR; Grunewald, GL; McLeish, MJ Phenylethanolamine N-methyltransferase inhibition: re-evaluation of kinetic data. Bioorg Med Chem Lett 14:4217-20 (2004) [PubMed]  Article 
Target
Name:
Phenylethanolamine N-methyltransferase
Synonyms:
Noradrenaline N-methyltransferase | PENT | PNMT | PNMT_HUMAN | PNMTase | Phenylethanolamine N-Methyltransferase (PNMT)
Type:
Enzyme
Mol. Mass.:
30852.66
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
282
Sequence:
MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGAFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
  
Inhibitor
Name:
BDBM50081952
Synonyms:
((R)-7-Bromo-1,2,3,4-tetrahydro-isoquinolin-3-yl)-methanol | (7-Bromo-1,2,3,4-tetrahydro-isoquinolin-3-yl)-methanol | CHEMBL337144
Type:
Small organic molecule
Emp. Form.:
C10H12BrNO
Mol. Mass.:
242.112
SMILES:
OC[C@H]1Cc2ccc(Br)cc2CN1
Structure:
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