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Target
Interleukin-17A
Ligand
BDBM50582228
Substrate
n/a
Meas. Tech.
ChEMBL_2153732 (CHEMBL5038279)
IC50
1.6±n/a nM
Citation
 Sabnis, RW Novel Difluorocyclohexyl Derivatives as IL-17 Modulators for Treating Inflammatory and Autoimmune Diseases. ACS Med Chem Lett 13:160-161 (2022) [PubMed]  Article 
Target
Name:
Interleukin-17A
Synonyms:
CTLA8 | Cytotoxic T-lymphocyte-associated antigen 8 | IL-17 | IL17 | IL17A | IL17_HUMAN | il-17a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
17511.44
Organism:
Homo sapiens (Human)
Description:
Q16552
Residue:
155
Sequence:
MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA
  
Inhibitor
Name:
BDBM50582228
Synonyms:
CHEMBL5077953
Type:
Small organic molecule
Emp. Form.:
C29H33F7N6O5S
Mol. Mass.:
710.663
SMILES:
CCc1nonc1C(=O)N[C@@H](C1CCC(F)(F)CC1)c1nc2c(F)c(ccc2[nH]1)[C@H](CCS(=O)(=O)CC)C(=O)N1CC(F)(F)C(F)(F)C1 |r|
Structure:
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