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Target
Carbonic anhydrase 12
Ligand
BDBM50582971
Substrate
n/a
Meas. Tech.
ChEMBL_2156360 (CHEMBL5041020)
Ki
7.3±n/a nM
Citation
 Elimam, DM; Eldehna, WM; Salem, R; Bonardi, A; Nocentini, A; Al-Rashood, ST; Elaasser, MM; Gratteri, P; Supuran, CT; Allam, HA Natural inspired ligustrazine-based SLC-0111 analogues as novel carbonic anhydrase inhibitors. Eur J Med Chem 228:0 (2022) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 12
Synonyms:
CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3
Type:
Enzyme
Mol. Mass.:
39456.00
Organism:
Homo sapiens (Human)
Description:
Catalytic domain of human cloned isozyme was used in the assay
Residue:
354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
  
Inhibitor
Name:
BDBM50582971
Synonyms:
CHEMBL5074754
Type:
Small organic molecule
Emp. Form.:
C16H18N4O5S
Mol. Mass.:
378.403
SMILES:
Cc1nc(C)c(nc1C)C(=O)OCC(=O)Nc1ccc(cc1)S(N)(=O)=O
Structure:
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