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Target
Myosin light chain kinase 2, skeletal/cardiac muscle
Ligand
BDBM50585202
Substrate
n/a
Meas. Tech.
ChEMBL_2161750 (CHEMBL5046611)
IC50
479±n/a nM
Citation
 Drewry, DH; Annor-Gyamfi, JK; Wells, CI; Pickett, JE; Dederer, V; Preuss, F; Mathea, S; Axtman, AD Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration. J Med Chem 65:1313-1328 (2022) [PubMed]  Article 
Target
Name:
Myosin light chain kinase 2, skeletal/cardiac muscle
Synonyms:
MYLK2 | MYLK2_HUMAN | myosin light chain kinase 2
Type:
PROTEIN
Mol. Mass.:
64687.13
Organism:
Homo sapiens (Human)
Description:
ChEMBL_586581
Residue:
596
Sequence:
MATENGAVELGIQNPSTDKAPKGPTGERPLAAGKDPGPPDPKKAPDPPTLKKDAKAPASEKGDGTLAQPSTSSQGPKGEGDRGGGPAEGSAGPPAALPQQTATPETSVKKPKAEQGASGSQDPGKPRVGKKAAEGQAAARRGSPAFLHSPSCPAIISSSEKLLAKKPPSEASELTFEGVPMTHSPTDPRPAKAEEGKNILAESQKEVGEKTPGQAGQAKMQGDTSRGIEFQAVPSEKSEVGQALCLTAREEDCFQILDDCPPPPAPFPHRMVELRTGNVSSEFSMNSKEALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLNHRNLIQLYAAIETPHEIVLFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNTTGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSMGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWLNNLAEKAKRCNRRLKSQILLKKYLMKRRWKKNFIAVSAANRFKKISSSGALMALGV
  
Inhibitor
Name:
BDBM50585202
Synonyms:
CHEMBL5091582
Type:
Small organic molecule
Emp. Form.:
C15H17F3N8
Mol. Mass.:
366.3443
SMILES:
Cc1nn(CC(F)(F)F)cc1Nc1nccc(NCCc2cnc[nH]2)n1
Structure:
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