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Target
Equilibrative nucleoside transporter 1
Ligand
BDBM50154699
Substrate
n/a
Meas. Tech.
ChEMBL_303353 (CHEMBL839668)
Ki
196±n/a nM
Citation
 Tromp, RA; van Ameijde, S; Pütz, C; Sundermann, C; Sundermann, B; von Frijtag Drabbe Künzel, JK; IJzerman, AP Inhibition of nucleoside transport by new analogues of 4-nitrobenzylthioinosine: replacement of the ribose moiety by substituted benzyl groups. J Med Chem 47:5441-50 (2004) [PubMed]  Article 
Target
Name:
Equilibrative nucleoside transporter 1
Synonyms:
ENT1 | Equilibrative NBMPR-sensitive nucleoside transporter | Equilibrative Nucleoside Transporter 1 (ENT1) | Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter | Equilibrative nucleoside transporter 1 | Nucleoside transporter, es-type | S29A1_HUMAN | SLC29A1 | Solute carrier family 29 member 1
Type:
Multi-pass membrane protein
Mol. Mass.:
50225.92
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
456
Sequence:
MTTSHQPQDRYKAVWLIFFMLGLGTLLPWNFFMTATQYFTNRLDMSQNVSLVTAELSKDAQASAAPAAPLPERNSLSAIFNNVMTLCAMLPLLLFTYLNSFLHQRIPQSVRILGSLVAILLVFLITAILVKVQLDALPFFVITMIKIVLINSFGAILQGSLFGLAGLLPASYTAPIMSGQGLAGFFASVAMICAIASGSELSESAFGYFITACAVIILTIICYLGLPRLEFYRYYQQLKLEGPGEQETKLDLISKGEEPRAGKEESGVSVSNSQPTNESHSIKAILKNISVLAFSVCFIFTITIGMFPAVTVEVKSSIAGSSTWERYFIPVSCFLTFNIFDWLGRSLTAVFMWPGKDSRWLPSLVLARLVFVPLLLLCNIKPRRYLTVVFEHDAWFIFFMAAFAFSNGYLASLCMCFGPKKVKPAEAETAGAIMAFFLCLGLALGAVFSFLFRAIV
  
Inhibitor
Name:
BDBM50154699
Synonyms:
2''-[6-(4-Nitro-benzylsulfanyl)-purin-9-ylmethyl]-biphenyl-3-ol | CHEMBL371196
Type:
Small organic molecule
Emp. Form.:
C25H19N5O3S
Mol. Mass.:
469.515
SMILES:
Oc1cccc(c1)-c1ccccc1Cn1cnc2c(SCc3ccc(cc3)[N+]([O-])=O)ncnc12
Structure:
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