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Target
Mu-type opioid receptor
Ligand
BDBM50155092
Substrate
n/a
Meas. Tech.
ChEBML_302753
Ki
9.4±n/a nM
Citation
 Coats, SJ; Schulz, MJ; Carson, JR; Codd, EE; Hlasta, DJ; Pitis, PM; Stone, DJ; Zhang, SP; Colburn, RW; Dax, SL Parallel methods for the preparation and SAR exploration of N-ethyl-4-[(8-alkyl-8-aza-bicyclo[3.2.1]oct-3-ylidene)-aryl-methyl]-benzamides, powerful mu and delta opioid agonists. Bioorg Med Chem Lett 14:5493-8 (2004) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOR-1 | Mor | OPIATE Mu | OPRM_MOUSE | Opioid receptors; mu and delta | Oprm | Oprm1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44431.62
Organism:
MOUSE
Description:
OPIATE Mu OPRM1 MOUSE::P42866
Residue:
398
Sequence:
MDSSAGPGNISDCSDPLAPASCSPAPGSWLNLSHVDGNQSDPCGPNRTGLGGSHSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSARIRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50155092
Synonyms:
4-{(3-Acetylamino-phenyl)-[8-(1H-imidazol-4-ylmethyl)-8-aza-bicyclo[3.2.1]oct-3-ylidene]-methyl}-N-ethyl-benzamide | CHEMBL185778
Type:
Small organic molecule
Emp. Form.:
C29H33N5O2
Mol. Mass.:
483.6046
SMILES:
CCNC(=O)c1ccc(cc1)C(=C1CC2CCC(C1)N2Cc1cnc[nH]1)c1cccc(NC(C)=O)c1 |(8.64,3.46,;7.32,4.22,;5.98,3.44,;4.63,4.2,;4.6,5.74,;3.31,3.44,;1.96,4.2,;.63,3.42,;.63,1.9,;1.96,1.12,;3.31,1.9,;-.7,1.12,;-.71,-.42,;-2.06,-1.17,;-2.06,-2.7,;-1.46,-1.59,;-.11,-1.59,;.58,-2.74,;.61,-1.2,;-.74,-3.5,;-.77,-5.03,;.55,-5.82,;1.95,-5.2,;2.97,-6.35,;2.18,-7.68,;.7,-7.34,;-2.02,1.9,;-2.02,3.44,;-3.35,4.2,;-4.69,3.44,;-4.69,1.9,;-6,1.14,;-6,-.38,;-4.69,-1.13,;-7.32,-1.13,;-3.35,1.12,)|
Structure:
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