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Target
Melatonin receptor type 1B
Ligand
BDBM50155721
Substrate
n/a
Meas. Tech.
ChEMBL_305097 (CHEMBL832401)
IC50
9.9±n/a nM
Citation
 Karageorge, GN; Bertenshaw, S; Iben, L; Xu, C; Sarbin, N; Gentile, A; Dubowchik, GM Tetrahydroisoquinoline derivatives as melatonin MT2 receptor antagonists. Bioorg Med Chem Lett 14:5881-4 (2004) [PubMed]  Article 
Target
Name:
Melatonin receptor type 1B
Synonyms:
MTNR1B | MTR1B_HUMAN | Mel-1B-R | Mel1b melatonin receptor | Melatonin 1B | Melatonin receptor | Melatonin receptor type 1B | Melatonin receptor type 2 (MT2)
Type:
Enzyme
Mol. Mass.:
40203.54
Organism:
Homo sapiens (Human)
Description:
P49286
Residue:
362
Sequence:
MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLLVILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVMGLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGSLEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRLCLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFNSCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQADAL
  
Inhibitor
Name:
BDBM50155721
Synonyms:
1-(2,2-Diphenyl-ethyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbaldehyde | CHEMBL364816
Type:
Small organic molecule
Emp. Form.:
C26H27NO3
Mol. Mass.:
401.4975
SMILES:
COc1cc2CCN(C=O)C(CC(c3ccccc3)c3ccccc3)c2cc1OC
Structure:
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