Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 1
Ligand
BDBM50156316
Substrate
n/a
Meas. Tech.
ChEMBL_305666 (CHEMBL827935)
IC50
4±n/a nM
Citation
 Luo, G; Mattson, GK; Bruce, MA; Wong, H; Murphy, BJ; Longhi, D; Antal-Zimanyi, I; Poindexter, GS Isosteric N-arylpiperazine replacements in a series of dihydropyridine NPY1 receptor antagonists. Bioorg Med Chem Lett 14:5975-8 (2004) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 1
Synonyms:
NPY-Y1 | NPY1-R | NPY1R | NPY1R_HUMAN | NPYR | NPYY1 | neuropeptide Y receptor Y1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44399.07
Organism:
Homo sapiens (Human)
Description:
NPY-Y1 NPY1R HUMAN::P25929
Residue:
384
Sequence:
MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
  
Inhibitor
Name:
BDBM50156316
Synonyms:
CHEMBL188576 | N-arylpiperazine derivative
Type:
Small organic molecule
Emp. Form.:
C32H38N8O6
Mol. Mass.:
630.6941
SMILES:
COC(=O)C1=C(C)[N-]C(C)=C(C1c1cccc(NC([N-]CCNC2CCN(CC2)c2ccccc2[N+]([O-])=O)=[NH+]C#N)c1)C(=[OH+])OC |w:38.41,c:4,9|
Structure:
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