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Target
Tyrosine-protein kinase Fgr
Ligand
BDBM13268
Substrate
n/a
Meas. Tech.
ChEMBL_304628 (CHEMBL828513)
IC50
<1±n/a nM
Citation
 Chen, P; Norris, D; Das, J; Spergel, SH; Wityak, J; Leith, L; Zhao, R; Chen, BC; Pitt, S; Pang, S; Shen, DR; Zhang, R; De Fex, HF; Doweyko, AM; McIntyre, KW; Shuster, DJ; Behnia, K; Schieven, GL; Barrish, JC Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56(Lck) inhibitors. Bioorg Med Chem Lett 14:6061-6 (2004) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase Fgr
Synonyms:
FGR | FGR_HUMAN | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | Proto-oncogene c-Fgr | SRC | SRC2 | p55-Fgr | p58-Fgr | p58c-Fgr
Type:
protein
Mol. Mass.:
59469.88
Organism:
Homo sapiens (Human)
Description:
P09769
Residue:
529
Sequence:
MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQAINPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGDQT
  
Inhibitor
Name:
BDBM13268
Synonyms:
BMS-354825 2-Heteroarylamino-thiazole Analog 12m | CHEMBL364623 | N-(2-Chloro-6-methylphenyl)-2-[(2,6-dimethyl-4-pyrimidinyl)-amino]-1,3-thiazole-5-carboxamide | N-(2-chloro-6-methylphenyl)-2-[(2,6-dimethylpyrimidin-4-yl)amino]-1,3-thiazole-5-carboxamide
Type:
Small organic molecule
Emp. Form.:
C17H16ClN5OS
Mol. Mass.:
373.86
SMILES:
Cc1cc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)nc(C)n1
Structure:
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