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Sodium channel protein type 7 subunit alpha
Ligand
BDBM145376
Substrate
n/a
Meas. Tech.
ChEMBL_2170557 (CHEMBL5055691)
IC50
2.3±n/a nM
Citation
Safina, BS; McKerrall, SJ; Sun, S; Chen, CA; Chowdhury, S; Jia, Q; Li, J; Zenova, AY; Andrez, JC; Bankar, G; Bergeron, P; Chang, JH; Chang, E; Chen, J; Dean, R; Decker, SM; DiPasquale, A; Focken, T; Hemeon, I; Khakh, K; Kim, A; Kwan, R; Lindgren, A; Lin, S; Maher, J; Mezeyova, J; Misner, D; Nelkenbrecher, K; Pang, J; Reese, R; Shields, SD; Sojo, L; Sheng, T; Verschoof, H; Waldbrook, M; Wilson, MS; Xie, Z; Young, C; Zabka, TS; Hackos, DH; Ortwine, DF; White, AD; Johnson, JP; Robinette, CL; Dehnhardt, CM; Cohen, CJ; Sutherlin, DP Discovery of Acyl-sulfonamide Na J Med Chem 64:2953-2966 (2021) [PubMed] Article More Info.:
Target
Name:
Sodium channel protein type 7 subunit alpha
Synonyms:
Putative voltage-gated sodium channel subunit alpha Nax | SCN6A | SCN7A | SCN7A_HUMAN | Sodium channel protein cardiac and skeletal muscle subunit alpha | Sodium channel protein type 7 subunit alpha | Sodium channel protein type VII subunit alpha
Type:
PROTEIN
Mol. Mass.:
193514.99
Organism:
Homo sapiens (Human)
Description:
ChEMBL_105639
Residue:
1682
Sequence:
MLASPEPKGLVPFTKESFELIKQHIAKTHNEDHEEEDLKPTPDLEVGKKLPFIYGNLSQGMVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGSFSFLGDPWNWLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRLMAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIEMKKRSPISTDTSLDVLEDATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKDCQLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAGQSWCIPFYLMVILIGNLLVLYLFLALVSSFSSCKDVTAEENNEAKNLQLAVARIKKGINYVLLKILCKTQNVPKDTMDHVNEVYVKEDISDHTLSELSNTQDFLKDKEKSSGTEKNATENESQSLIPSPSVSETVPIASGESDIENLDNKEIQSKSGDGGSKEKIKQSSSSECSTVDIAISEEEEMFYGGERSKHLKNGCRRGSSLGQISGASKKGKIWQNIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMAYGFKAYFSNGWYRLDFVVVIVFCLSLIGKTREELKPLISMKFLRPLRVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGERFPSSEVMNKSRCESLLFNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQRPVPRPLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSIFVMLYTMECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYVKKEAGINDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYFVSYILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDRTQYIDSSKLSDFAAALDPPLFMAKPNKGQLIALDLPMAVGDRIHCLDILLAFTKRVMGQDVRMEKVVSEIESGFLLANPFKITCEPITTTLKRKQEAVSATIIQRAYKNYRLRRNDKNTSDIHMIDGDRDVHATKEGAYFDKAKEKSPIQSQI
Inhibitor
Name:
BDBM145376
Synonyms:
US8952169, 155
Type:
Small organic molecule
Emp. Form.:
C25H33FN2O5S
Mol. Mass.:
492.603
SMILES:
Fc1cc(OCC23CC4CC(CC(C4)C2)C3)c(cc1C(=O)NS(=O)(=O)N1CCOCC1)C1CC1 |TLB:15:6:13:9.10.11,THB:5:6:13:9.10.11,15:10:13:6.14.7,14:6:9:13.12.11,14:12:9:6.15.7|
Structure:
