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Target
Prostaglandin E2 receptor EP3 subtype
Ligand
BDBM50156546
Substrate
n/a
Meas. Tech.
ChEMBL_429535 (CHEMBL918076)
Ki
77000±n/a nM
Citation
 Elworthy, TR; Brill, ER; Chiou, SS; Chu, F; Harris, JR; Hendricks, RT; Huang, J; Kim, W; Lach, LK; Mirzadegan, T; Yee, C; Walker, KA Lactams as EP4 prostanoid receptor agonists. 3. Discovery of N-ethylbenzoic acid 2-pyrrolidinones as subtype selective agents. J Med Chem 47:6124-7 (2004) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP3 subtype
Synonyms:
PE2R3_HUMAN | PGE receptor, EP3 subtype | PGE2-R | PTGER3 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP3 subtype | Prostaglandin E2 receptor EP3 subtype (EP3) | Prostaglandin E2 receptor EP3A subtype (EP3A) | Prostaglandin E2 receptor EP3D subtype (EP3D) | Prostanoid EP3 receptor
Type:
Enzyme
Mol. Mass.:
43335.03
Organism:
Homo sapiens (Human)
Description:
P43115
Residue:
390
Sequence:
MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRYHTNNYASSSTSLPCQCSSTLMWSDHLER
  
Inhibitor
Name:
BDBM50156546
Synonyms:
4-(2-((S)-2-((S)-5-cyclobutyl-3-hydroxypentyl)-5-oxopyrrolidin-1-yl)ethyl)benzoic acid | CHEMBL223744
Type:
Small organic molecule
Emp. Form.:
C22H31NO4
Mol. Mass.:
373.4858
SMILES:
O[C@@H](CCC1CCC1)CC[C@H]1CCC(=O)N1CCc1ccc(cc1)C(O)=O |r|
Structure:
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