Reaction Details Report a problem with these data
Target
Prostaglandin E2 receptor EP2 subtype
Ligand
BDBM50156553
Substrate
n/a
Meas. Tech.
ChEMBL_429534 (CHEMBL918075)
Ki
75±n/a nM
Citation
 Elworthy, TR; Brill, ER; Chiou, SS; Chu, F; Harris, JR; Hendricks, RT; Huang, J; Kim, W; Lach, LK; Mirzadegan, T; Yee, C; Walker, KA Lactams as EP4 prostanoid receptor agonists. 3. Discovery of N-ethylbenzoic acid 2-pyrrolidinones as subtype selective agents. J Med Chem 47:6124-7 (2004) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP2 subtype
Synonyms:
PE2R2_HUMAN | PGE receptor EP2 subtype | PTGER2 | Prostaglandin E2 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP4 subtype | Prostanoid EP2 Receptor
Type:
Enzyme
Mol. Mass.:
39775.71
Organism:
Homo sapiens (Human)
Description:
P43116
Residue:
358
Sequence:
MGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGRRSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCFIRHGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGSGRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSCSTQSDASKQADL
  
Inhibitor
Name:
BDBM50156553
Synonyms:
4-(2-((R)-2-((S,E)-5-cyclobutyl-3-hydroxypent-1-enyl)-5-oxopyrrolidin-1-yl)ethyl)benzoic acid | CHEMBL222782
Type:
Small organic molecule
Emp. Form.:
C22H29NO4
Mol. Mass.:
371.47
SMILES:
O[C@@H](CCC1CCC1)\C=C\[C@H]1CCC(=O)N1CCc1ccc(cc1)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: