Reaction Details Report a problem with these data
Target
Transient receptor potential cation channel subfamily V member 2
Ligand
BDBM50511105
Substrate
n/a
Meas. Tech.
ChEMBL_2184546 (CHEMBL5096628)
IC50
800±n/a nM
Citation
 Sampson, PB Phytocannabinoid Pharmacology: Medicinal Properties of  J Nat Prod 84:142-160 (2021) [PubMed] 
Target
Name:
Transient receptor potential cation channel subfamily V member 2
Synonyms:
OTRPC2 | Osm-9-like TRP channel 2 | TRPV2 | TRPV2_HUMAN | Transient receptor potential cation channel subfamily V member 2 | VRL | VRL-1 | Vanilloid receptor-like protein 1
Type:
PROTEIN
Mol. Mass.:
85972.07
Organism:
Homo sapiens
Description:
ChEMBL_101052
Residue:
764
Sequence:
MTSPSSSPVFRLETLDGGQEDGSEADRGKLDFGSGLPPMESQFQGEDRKFAPQIRVNLNYRKGTGASQPDPNRFDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKDGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQREFSGLSHLSRKFTEWCYGPVRVSLYDLASVDSCEENSVLEIIAFHCKSPHRHRMVVLEPLNKLLQAKWDLLIPKFFLNFLCNLIYMFIFTAVAYHQPTLKKQAAPHLKAEVGNSMLLTGHILILLGGIYLLVGQLWYFWRRHVFIWISFIDSYFEILFLFQALLTVVSQVLCFLAIEWYLPLLVSALVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLIYLVFLFGFAVALVSLSQEAWRPEAPTGPNATESVQPMEGQEDEGNGAQYRGILEASLELFKFTIGMGELAFQEQLHFRGMVLLLLLAYVLLTYILLLNMLIALMSETVNSVATDSWSIWKLQKAISVLEMENGYWWCRKKQRAGVMLTVGTKPDGSPDERWCFRVEEVNWASWEQTLPTLCEDPSGAGVPRTLENPVLASPPKEDEDGASEENYVPVQLLQSN
  
Inhibitor
Name:
BDBM50511105
Synonyms:
GWP-42004 | Gwp42004 | O-4394 | THCV | Tetrahydrocannabivarin
Type:
Small organic molecule
Emp. Form.:
C19H26O2
Mol. Mass.:
286.4085
SMILES:
[H][C@@]12C=C(C)CC[C@@]1([H])C(C)(C)Oc1cc(CCC)cc(O)c21 |r,t:2|
Structure:
Search PDB for entries with ligand similarity: