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Target
Casein kinase I isoform alpha
Ligand
BDBM50587736
Substrate
n/a
Meas. Tech.
ChEMBL_2184917 (CHEMBL5096999)
Kd
1.000000±n/a nM
Citation
 Wen, J; Hadden, MK Medulloblastoma drugs in development: Current leads, trials and drawbacks. Eur J Med Chem 215:0 (2021) [PubMed] 
Target
Name:
Casein kinase I isoform alpha
Synonyms:
CK1 | CKI-alpha | CSNK1A1 | Casein Kinase I | Casein kinase 1 alpha (CK1 alpha) | Casein kinase I isoform alpha/delta | KC1A_HUMAN
Type:
Serine/threonine-protein kinase
Mol. Mass.:
38936.59
Organism:
Homo sapiens (Human)
Description:
P48729
Residue:
337
Sequence:
MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMKGF
  
Inhibitor
Name:
BDBM50587736
Synonyms:
CHEBI:8687 | PYRVINIUM | Pyrvinium | Pyrvinium (cation) | Pyrvinium cation | Pyrvinium hydroxide | Pyrvinium ion | Pyrvinum (base)
Type:
Small organic molecule
Emp. Form.:
C26H28N3
Mol. Mass.:
382.5201
SMILES:
CN(C)c1ccc2[n+](C)c(\C=C\c3cc(C)n(c3C)-c3ccccc3)ccc2c1
Structure:
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