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Target
Melanocortin receptor 4
Ligand
BDBM50119367
Substrate
n/a
Meas. Tech.
ChEMBL_430483 (CHEMBL917732)
IC50
0.300000±n/a nM
Citation
 Chen, C; Pontillo, J; Fleck, BA; Gao, Y; Wen, J; Tran, JA; Tucci, FC; Marinkovic, D; Foster, AC; Saunders, J 4-{(2R)-[3-Aminopropionylamido]-3-(2,4-dichlorophenyl)propionyl}-1-{2-[(2-thienyl)ethylaminomethyl]phenyl}piperazine as a potent and selective melanocortin-4 receptor antagonist--design, synthesis, and characterization. J Med Chem 47:6821-30 (2004) [PubMed]  Article 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM50119367
Synonyms:
(3R)-N-[(2R)-3-(4-chlorophenyl)-1-{4-cyclohexyl-4-[(1-methyl-1H-1,2,3,4-tetrazol-5-yl)methyl]piperidin-1-yl}-1-oxopropan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide | 1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid {1-(4-chloro-benzyl)-2-[4-cyclohexyl-4-(1-methyl-1H-tetrazol-5-ylmethyl)-piperidin-1-yl]-2-oxo-ethyl}-amide | CHEMBL140154
Type:
Small organic molecule
Emp. Form.:
C33H42ClN7O2
Mol. Mass.:
604.185
SMILES:
Cn1nnnc1CC1(CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H]1Cc2ccccc2CN1)C1CCCCC1
Structure:
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