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Target
Tubulin beta-1 chain
Ligand
BDBM50095316
Substrate
n/a
Meas. Tech.
ChEMBL_305199 (CHEMBL832453)
IC50
>100000±n/a nM
Citation
 Ducki, S; Mackenzie, G; Lawrence, NJ; Snyder, JP Quantitative structure-activity relationship (5D-QSAR) study of combretastatin-like analogues as inhibitors of tubulin assembly. J Med Chem 48:457-65 (2005) [PubMed]  Article 
Target
Name:
Tubulin beta-1 chain
Synonyms:
TBB1_HUMAN | TUBB1
Type:
PROTEIN
Mol. Mass.:
50311.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_305173
Residue:
451
Sequence:
MREIVHIQIGQCGNQIGAKFWEMIGEEHGIDLAGSDRGASALQLERISVYYNEAYGRKYVPRAVLVDLEPGTMDSIRSSKLGALFQPDSFVHGNSGAGNNWAKGHYTEGAELIENVLEVVRHESESCDCLQGFQIVHSLGGGTGSGMGTLLMNKIREEYPDRIMNSFSVMPSPKVSDTVVEPYNAVLSIHQLIENADACFCIDNEALYDICFRTLKLTTPTYGDLNHLVSLTMSGITTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTAQGSQQYRALSVAELTQQMFDARNTMAACDLRRGRYLTVACIFRGKMSTKEVDQQLLSVQTRNSSCFVEWIPNNVKVAVCDIPPRGLSMAATFIGNNTAIQEIFNRVSEHFSAMFKRKAFVHWYTSEGMDINEFGEAENNIHDLVSEYQQFQDAKAVLEEDEEVTEEAEMEPEDKGH
  
Inhibitor
Name:
BDBM50095316
Synonyms:
3-[2-Methoxy-5-(3,4,5-trimethoxy-phenoxymethyl)-phenoxy]-propane-1,2-diol | CHEMBL358037
Type:
Small organic molecule
Emp. Form.:
C20H26O8
Mol. Mass.:
394.4156
SMILES:
COc1ccc(COc2cc(OC)c(OC)c(OC)c2)cc1OCC(O)CO
Structure:
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