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Target
Receptor-interacting serine/threonine-protein kinase 3
Ligand
BDBM50588536
Substrate
n/a
Meas. Tech.
ChEMBL_2187422 (CHEMBL5099504)
Kd
>5000±n/a nM
Citation
 Sun, Y; Xu, L; Shao, H; Quan, D; Mo, Z; Wang, J; Zhang, W; Yu, J; Zhuang, C; Xu, K Discovery of a Trifluoromethoxy Cyclopentanone Benzothiazole Receptor-Interacting Protein Kinase 1 Inhibitor as the Treatment for Alzheimer's Disease. J Med Chem 65:14957-14969 (2022) [PubMed] 
Target
Name:
Receptor-interacting serine/threonine-protein kinase 3
Synonyms:
RIP-3 | RIP-like protein kinase 3 | RIP3 | RIPK3 | RIPK3_HUMAN | Receptor-interacting protein 3
Type:
PROTEIN
Mol. Mass.:
56886.12
Organism:
Homo sapiens (Human)
Description:
ChEMBL_881455
Residue:
518
Sequence:
MSCVKLWPSGAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISREVKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNKLNLEEPPSSVPKKCPSLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQTPETSTFRNQMPSPTSTGTPSPGPRGNQGAERQGMNWSCRTPEPNPVTGRPLVNIYNCSGVQVGDNNYLTMQQTTALPTWGLAPSGKGRGLQHPPPVGSQEGPKDPEAWSRPQGWYNHSGK
  
Inhibitor
Name:
BDBM50588536
Synonyms:
CHEMBL5172295
Type:
Small organic molecule
Emp. Form.:
C27H18F5N3O5S
Mol. Mass.:
591.506
SMILES:
Fc1ccc(Oc2cc3nc(NC(=O)C4CC(=O)C4)sc3cc2F)cc1NC(=O)Cc1cccc(OC(F)(F)F)c1
Structure:
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