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Target
Adenosine receptor A2b
Ligand
BDBM50159962
Substrate
n/a
Meas. Tech.
ChEMBL_303604 (CHEMBL829693)
Ki
1450±n/a nM
Citation
 Zablocki, J; Kalla, R; Perry, T; Palle, V; Varkhedkar, V; Xiao, D; Piscopio, A; Maa, T; Gimbel, A; Hao, J; Chu, N; Leung, K; Zeng, D The discovery of a selective, high affinity A(2B) adenosine receptor antagonist for the potential treatment of asthma. Bioorg Med Chem Lett 15:609-12 (2005) [PubMed]  Article 
Target
Name:
Adenosine receptor A2b
Synonyms:
AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36341.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
332
Sequence:
MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL
  
Inhibitor
Name:
BDBM50159962
Synonyms:
8-{4-[3-(3-Fluoro-phenyl)-[1,2,4]oxadiazol-5-ylmethoxy]-phenyl}-1,3-dipropyl-3,7-dihydro-purine-2,6-dione | CHEMBL181468
Type:
Small organic molecule
Emp. Form.:
C26H25FN6O4
Mol. Mass.:
504.5129
SMILES:
CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1ccc(OCc2nc(no2)-c2cccc(F)c2)cc1
Structure:
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