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Target
Carbonic anhydrase 12
Ligand
BDBM50589095
Substrate
n/a
Meas. Tech.
ChEMBL_2191940 (CHEMBL5104300)
IC50
>360±n/a nM
Citation
 Kumar, S; Rulhania, S; Jaswal, S; Monga, V Recent advances in the medicinal chemistry of carbonic anhydrase inhibitors. Eur J Med Chem 209:0 (2021) [PubMed] 
Target
Name:
Carbonic anhydrase 12
Synonyms:
CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3
Type:
Enzyme
Mol. Mass.:
39456.00
Organism:
Homo sapiens (Human)
Description:
Catalytic domain of human cloned isozyme was used in the assay
Residue:
354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
  
Inhibitor
Name:
BDBM50589095
Synonyms:
CHEMBL5175019
Type:
Small organic molecule
Emp. Form.:
C15H11ClN2O2
Mol. Mass.:
286.713
SMILES:
Cn1c(nc2cc(ccc12)C(O)=O)-c1ccc(Cl)cc1
Structure:
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