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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50160488
Substrate
n/a
Meas. Tech.
ChEMBL_305087 (CHEMBL832392)
IC50
140±n/a nM
Citation
 Hashimoto, K; Tatsuta, M; Kataoka, M; Yasoshima, K; Shogase, Y; Shimazaki, M; Yura, T; Li, Y; Yamamoto, N; Gupta, JB; Urbahns, K Benzimidazole derivatives as novel nonpeptide luteinizing hormone-releasing hormone (LHRH) antagonists. Part 1: Benzimidazole-5-sulfonamides. Bioorg Med Chem Lett 15:799-803 (2005) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr
Type:
PROTEIN
Mol. Mass.:
37767.60
Organism:
Rattus norvegicus
Description:
ChEMBL_1335047
Residue:
327
Sequence:
MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50160488
Synonyms:
1-Benzyl-2-(2-pyridin-3-yl-ethylsulfanyl)-1H-benzoimidazole-5-sulfonic acid 4-fluoro-benzylamide | CHEMBL183066 | N-(4-fluorobenzyl)-1-benzyl-2-(2-(pyridin-3-yl)ethylthio)-1H-benzo[d]imidazole-5-sulfonamide
Type:
Small organic molecule
Emp. Form.:
C28H25FN4O2S2
Mol. Mass.:
532.652
SMILES:
Fc1ccc(CNS(=O)(=O)c2ccc3n(Cc4ccccc4)c(SCCc4cccnc4)nc3c2)cc1
Structure:
Search PDB for entries with ligand similarity: