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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50160492
Substrate
n/a
Meas. Tech.
ChEMBL_305163 (CHEMBL832753)
IC50
490.0±n/a nM
Citation
 Hashimoto, K; Tatsuta, M; Kataoka, M; Yasoshima, K; Shogase, Y; Shimazaki, M; Yura, T; Li, Y; Yamamoto, N; Gupta, JB; Urbahns, K Benzimidazole derivatives as novel nonpeptide luteinizing hormone-releasing hormone (LHRH) antagonists. Part 1: Benzimidazole-5-sulfonamides. Bioorg Med Chem Lett 15:799-803 (2005) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH)
Type:
Enzyme
Mol. Mass.:
37749.45
Organism:
Homo sapiens (Human)
Description:
P30968
Residue:
328
Sequence:
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50160492
Synonyms:
CHEMBL183572 | [1-Benzyl-5-(4-fluoro-benzylsulfamoyl)-1H-benzoimidazol-2-ylsulfanyl]-acetic acid ethyl ester
Type:
Small organic molecule
Emp. Form.:
C25H24FN3O4S2
Mol. Mass.:
513.604
SMILES:
CCOC(=O)CSc1nc2cc(ccc2n1Cc1ccccc1)S(=O)(=O)NCc1ccc(F)cc1
Structure:
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