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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50160522
Substrate
n/a
Meas. Tech.
ChEMBL_305571 (CHEMBL827165)
IC50
79±n/a nM
Citation
 Li, Y; Kataoka, M; Tatsuta, M; Yasoshima, K; Yura, T; Urbahns, K; Kiba, A; Yamamoto, N; Gupta, JB; Hashimoto, K Benzimidazole derivatives as novel nonpeptide luteinizing hormone-releasing hormone (LHRH) antagonists. Part 2: Benzimidazole-5-sulfonamides. Bioorg Med Chem Lett 15:805-7 (2005) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr
Type:
PROTEIN
Mol. Mass.:
37767.60
Organism:
Rattus norvegicus
Description:
ChEMBL_1335047
Residue:
327
Sequence:
MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50160522
Synonyms:
1-Benzyl-2-[2-(3-isopropyl-ureido)-ethyl]-1H-benzoimidazole-5-sulfonic acid 4-fluoro-benzylamide | CHEMBL183325
Type:
Small organic molecule
Emp. Form.:
C27H30FN5O3S
Mol. Mass.:
523.622
SMILES:
CC(C)NC(=O)NCCc1nc2cc(ccc2n1Cc1ccccc1)S(=O)(=O)NCc1ccc(F)cc1
Structure:
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