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Target
4-hydroxy-tetrahydrodipicolinate synthase
Ligand
BDBM50160721
Substrate
n/a
Meas. Tech.
ChEMBL_302898 (CHEMBL830359)
Ki
170000±n/a nM
Citation
 Turner, JJ; Healy, JP; Dobson, RC; Gerrard, JA; Hutton, CA Two new irreversible inhibitors of dihydrodipicolinate synthase: diethyl (E,E)-4-oxo-2,5-heptadienedioate and diethyl (E)-4-oxo-2-heptenedioate. Bioorg Med Chem Lett 15:995-8 (2005) [PubMed]  Article 
Target
Name:
4-hydroxy-tetrahydrodipicolinate synthase
Synonyms:
DAPA_ECOLI | Dihydrodipicolinate synthase | dapA
Type:
PROTEIN
Mol. Mass.:
31269.12
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_536816
Residue:
292
Sequence:
MFTGSIVAIVTPMDEKGNVCRASLKKLIDYHVASGTSAIVSVGTTGESATLNHDEHADVVMMTLDLADGRIPVIAGTGANATAEAISLTQRFNDSGIVGCLTVTPYYNRPSQEGLYQHFKAIAEHTDLPQILYNVPSRTGCDLLPETVGRLAKVKNIIGIKEATGNLTRVNQIKELVSDDFVLLSGDDASALDFMQLGGHGVISVTANVAARDMAQMCKLAAEGHFAEARVINQRLMPLHNKLFVEPNPIPVKWACKELGLVATDTLRLPMTPITDSGRETVRAALKHAGLL
  
Inhibitor
Name:
BDBM50160721
Synonyms:
2-Oxo-heptanedioic acid | 2-oxoheptanedioic acid | CHEMBL185075 | alpha-ketopimelic acid
Type:
Small organic molecule
Emp. Form.:
C7H10O5
Mol. Mass.:
174.1513
SMILES:
OC(=O)CCCCC(=O)C(O)=O
Structure:
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