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Target
RNA-directed RNA polymerase
Ligand
BDBM50160862
Substrate
n/a
Meas. Tech.
ChEMBL_305682 (CHEMBL828054)
IC50
3200±n/a nM
Citation
 Mashino, T; Shimotohno, K; Ikegami, N; Nishikawa, D; Okuda, K; Takahashi, K; Nakamura, S; Mochizuki, M Human immunodeficiency virus-reverse transcriptase inhibition and hepatitis C virus RNA-dependent RNA polymerase inhibition activities of fullerene derivatives. Bioorg Med Chem Lett 15:1107-9 (2005) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50160862
Synonyms:
CHEMBL2373486 | Fullerene Derivative
Type:
Small organic molecule
Emp. Form.:
C66H10O8
Mol. Mass.:
930.7808
SMILES:
[H][C@@]12C3=C4c5c6c7-c8c9c%10c%11c%12c%13c%14c%15c%16c%17c%13c%13c%11c%11c%10c%10c8[C@]8([H])c%18c%19c%20c%21c(c3c3c1c(c%16c1c3c%21c3c%16c%20c(c%10%18)c%11c%16c%13c%17c13)c%15=C1[C@]2([H])c5c2c7[C@]9([H])[C@]%12([H])[C@@]%143C(C(O)=O)(C(O)=O)[C@]123)[C@@]%191C(C(O)=O)(C(O)=O)[C@]41[C@]68[H] |c:2,t:68|
Structure:
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