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Target
Alpha-enolase
Ligand
BDBM50543109
Substrate
n/a
Meas. Tech.
ChEMBL_2194997 (CHEMBL5107357)
IC50
5900±n/a nM
Citation
 Yan, VC; Pham, CD; Ballato, ES; Yang, KL; Arthur, K; Khadka, S; Barekatain, Y; Shrestha, P; Tran, T; Poral, AH; Washington, M; Raghavan, S; Czako, B; Pisaneschi, F; Lin, YH; Satani, N; Hammoudi, N; Ackroyd, JJ; Georgiou, DK; Millward, SW; Muller, FL Prodrugs of a 1-Hydroxy-2-oxopiperidin-3-yl Phosphonate Enolase Inhibitor for the Treatment of  J Med Chem 65:13813-13832 (2022) [PubMed] 
Target
Name:
Alpha-enolase
Synonyms:
2-phospho-D-glycerate hydro-lyase | 4.2.1.11 | C-myc promoter-binding protein | ENO1 | ENO1L1 | ENOA_HUMAN | Enolase 1 | Enolase 1 (ENO1) | MBP-1 | MBPB1 | MPB-1 | MPB1 | NNE | Non-neural enolase | Phosphopyruvate hydratase | Plasminogen-binding protein
Type:
n/a
Mol. Mass.:
47171.43
Organism:
Homo sapiens (Human)
Description:
P06733
Residue:
434
Sequence:
MSILKIHAREIFDSRGNPTVEVDLFTSKGLFRAAVPSGASTGIYEALELRDNDKTRYMGKGVSKAVEHINKTIAPALVSKKLNVTEQEKIDKLMIEMDGTENKSKFGANAILGVSLAVCKAGAVEKGVPLYRHIADLAGNSEVILPVPAFNVINGGSHAGNKLAMQEFMILPVGAANFREAMRIGAEVYHNLKNVIKEKYGKDATNVGDEGGFAPNILENKEGLELLKTAIGKAGYTDKVVIGMDVAASEFFRSGKYDLDFKSPDDPSRYISPDQLADLYKSFIKDYPVVSIEDPFDQDDWGAWQKFTASAGIQVVGDDLTVTNPKRIAKAVNEKSCNCLLLKVNQIGSVTESLQACKLAQANGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLLRIEEELGSKAKFAGRNFRNPLAK
  
Inhibitor
Name:
BDBM50543109
Synonyms:
CHEMBL4647387
Type:
Small organic molecule
Emp. Form.:
C5H10NO5P
Mol. Mass.:
195.1104
SMILES:
ON1CCCC(C1=O)P(O)(O)=O
Structure:
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