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Target
Protein mono-ADP-ribosyltransferase PARP11
Ligand
BDBM50590269
Substrate
n/a
Meas. Tech.
ChEMBL_2195786 (CHEMBL5108302)
IC50
200±n/a nM
Citation
 Kirby, IT; Person, A; Cohen, M Rational design of selective inhibitors of PARP4. RSC Med Chem 12:1950-1957 (2021) [PubMed] 
Target
Name:
Protein mono-ADP-ribosyltransferase PARP11
Synonyms:
2.4.2.30 | ADP-ribosyltransferase diphtheria toxin-like 11 | ARTD11 | C12orf6 | PAR11_HUMAN | PARP-11 | PARP11 | Poly [ADP-ribose] polymerase 11
Type:
PROTEIN
Mol. Mass.:
39601.40
Organism:
Homo sapiens
Description:
ChEMBL_107591
Residue:
338
Sequence:
MWEANPEMFHKAEELFSKTTNNEVDDMDTSDTQWGWFYLAECGKWHMFQPDTNSQCSVSSEDIEKSFKTNPCGSISFTTSKFSYKIDFAEMKQMNLTTGKQRLIKRAPFSISAFSYICENEAIPMPPHWENVNTQVPYQLIPLHNQTHEYNEVANLFGKTMDRNRIKRIQRIQNLDLWEFFCRKKAQLKKKRGVPQINEQMLFHGTSSEFVEAICIHNFDWRINGIHGAVFGKGTYFARDAAYSSRFCKDDIKHGNTFQIHGVSLQQRHLFRTYKSMFLARVLIGDYINGDSKYMRPPSKDGSYVNLYDSCVDDTWNPKIFVVFDANQIYPEYLIDFH
  
Inhibitor
Name:
BDBM50590269
Synonyms:
CHEMBL5187963
Type:
Small organic molecule
Emp. Form.:
C14H12N4OS
Mol. Mass.:
284.336
SMILES:
Cc1cccc2c1nc(CSc1ncccn1)[nH]c2=O
Structure:
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