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Target
Elongin-C
Ligand
BDBM50590277
Substrate
n/a
Meas. Tech.
ChEMBL_2195889 (CHEMBL5108405)
Ki
2058±n/a nM
Citation
 de Castro, GV; Ciulli, A Estimating the cooperativity of PROTAC-induced ternary complexes using  RSC Med Chem 12:1765-1770 (2021) [PubMed] 
Target
Name:
Elongin-C
Synonyms:
ELOC | ELOC_HUMAN | Elongin 15 kDa subunit | Elongin-C | RNA polymerase II transcription factor SIII subunit C | SIII p15 | TCEB1 | Transcription elongation factor B polypeptide 1
Type:
PROTEIN
Mol. Mass.:
12466.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108414
Residue:
112
Sequence:
MDGEEKTYGGCEGPDAMYVKLISSDGHEFIVKREHALTSGTIKAMLSGPGQFAENETNEVNFREIPSHVLSKVCMYFTYKVRYTNSSTEIPEFPIAPEIALELLMAANFLDC
  
Inhibitor
Name:
BDBM50590277
Synonyms:
CHEMBL5176799
Type:
Small organic molecule
Emp. Form.:
C49H59ClFN9O8S2
Mol. Mass.:
1020.63
SMILES:
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2[C@H](F)[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C[C@@H]2N=C(c3c(C)c(C)sc3-n3c(C)nnc23)c2ccc(Cl)cc2)C(C)(C)C)cc1 |r,c:44|
Structure:
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